Nature can be likened, as Darwin suggested, to a tangled bank, full of diverse forms. At first glance, that bank appears chaotic, but over the centuries, we have discovered that all life is united by a general mathematics that sets the boundaries for maintenance, growth, and reproduction. The harmony of this mathematics is manifest in the repeating patterns that emerge across the Tree of Life. But, what are the general physical and chemical laws that govern the origin and maintenance of life? And, how do we synthesize them into a single, unified theory? This project will conceptually and empirically propel a new, unified discipline on the laws of life; specifically, on how shared constraints across scales of organization contribute to large-scale patterns of direction and causality in evolution. Specifically, we propose a novel framework that synthesizes "top-down" macroevolutionary approaches with "bottom-up" principles based on biochemistry into the common language of the adaptive landscape to infer causality in evolution.
As a unified gestalt, the proposed theory will reveal laws immutable to life, and establish a universal language for identifying and interpreting constraint and direction in evolution.
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